Posted by blueberry1 on January 20, 2007, at 8:25:45
In reply to Zoloft and dopamine reuptake inhibition, posted by Quintal on January 19, 2007, at 21:12:03
I don't remember where I saw it, but there was a chart showing the affinity of wellbutrin versus zoloft for dopamine reuptake. Zoloft was significantly higher than wellbutrin. But it went on to explain that the chart is deceiving, because at therapeutic doses wellbutrin is actually higher. They said it takes 300mg zoloft for the dopamine part to kick in. They also said that it is not wellbutrin itself that has the dopamine action, but rather its metabolites that are 20 times stronger than the wellbutrin itself. And that depending on how a person's unique chemistry breaks down and metabolizes wellbutrin, the effects vary, resulting in either increased effectiveness or increased adverse effects with less effectiveness.
The one time I tried zoloft I swear I felt dopamine the very first day. It felt a lot like when I tried tyrosine supplements. And that was at just 25mg.
So who knows. I don't think any website or researcher really does. It either works or it doesn't, and it's just that simple.
I've tried dopamine strategies, such as tyrosine, low dose amisulpride, ritalin and adderall. They did not increase pleasure at all. But they did increase motivation to get things done. Motivation to do them, but no pleasure in doing them. So I wonder about dopamine's reputation as the pleasure chemical. I believe the whole thing is much more complicated, involving interplay between all the chemicals. You can't change one without causing a cascade effect that changes the others.
Anyway, zoloft and dopamine? It felt that way to me. Lexapro on the other hand felt like pure serotonin, very much like taking 5htp supplements.
poster:blueberry1
thread:724214
URL: http://www.dr-bob.org/babble/20070119/msgs/724354.html