Posted by Klavot on January 20, 2007, at 2:53:48
In reply to Re: Zoloft and dopamine reuptake inhibition » halcyondaze, posted by Quintal on January 20, 2007, at 0:02:44
I too have read that Zoloft has substantial dopamine reuptake inhibition properties. Strange though, the package insert states that
"Sertraline has only weak effects on neuronal reuptake of norepinephrine and dopamine."
(see e.g. http://home.intekom.com/pharm/pfizer/zoloft-t.html ).
You'd think that if Zoloft *did* inhibit dopamine reuptake significantly, Pfizer would promote it as such, since dopamine reuptake is supposed to be good.
I might add that the precise mechanism of action of Wellbutrin has not been fully elucidated. Its dopaminergic effect may entail more than just simple dopamine reuptake inhibition. So indeed, Zoloft may inhibit dopamine reuptake more than Wellbutrin, but that does not mean that it has a greater dopaminergic effect.
Finally, dopamine isn't quite the miracle amine that it is often portrayed as. Studies have shown that dopamine regulates *desire* rather than *pleasure*, see e.g.
http://en.wikipedia.org/wiki/Dopamine
That dopaminergic drugs often improve motivation is likely because they increase desire, not pleasure.
Klavot
poster: Klavot
thread:724214
URL: http://www.dr-bob.org/babble/20070119/msgs/724316.html