Posted by Tomatheus on January 12, 2007, at 1:18:36
In reply to About my over seas., posted by willyee on January 10, 2007, at 7:32:09
Willyee,
See below for my responses to various portions of your post...
> --- Glaxco Smith brand,well same as usual,red rose colored,silky with what I BELIEVE is the name of the company,although i am sure there is some sort of imprint on it.Resemble M&M`S fairly thick.
Yep. Parnate tablets are labeled with the text "Parnate SB." The "SB" stands for SmithKline Beecher, which merged with Glaxo Wellcome in 2000 to form GlaxoSmithKline. I'm not sure why they never relabeled the tablets to say something like "Parnate GSK" instead of "Parnate SB," but according to this year's Physicians' Desk Reference (Thomson PDR, 2007), the tablets are still "debossed with the product name PARNATE and SB."
The inactive ingredients in GSK's current formulation of Parnate include cellulose, citric acid, croscarmellose sodium, D&C Red No. 7, FD&C Blue No. 2, FD&C Red No. 40, FD&C Yellow No. 6, gelatin, lactose, magnesium stearate, talc, titanium dioxide, and trace amounts of other inactive incredients (Thomson PDR, 2007).
The PDR also described Parnate tablets as being "round," "rose-red," and "film-coated."
> --- U.S Based generic,still fairly thick,no imprinting,not silky,resembles the current nardil tabs,however the generic parnate do seem to be built well and hold togther.
I have never personally taken the generic version of Parnate that's available in the U.S. (manufactured by Kali Laboratories, a subsidiary of Par Pharmaceutical Companies, Inc.), but some of the things that I've read about it seem to be consistent with what you've written.
The prescribing information document for the generic tranylcypromine sulfate product that's available in the U.S. (Par Pharmaceutical Companies, Inc., 2006) includes the following statements under the "Description" heading:
"Chemically, tranylcypromine sulfate is (+/-)-trans-2-phenylcyclopropylamine sulfate (2:1)."
"Each round, dark pink, film-coated tablet is debossed with '250' on one side and 'K' on the other side and contains tranylcypromine sulfate equivalent to 10 mg of tranylcypromine. Inactive ingredients consist of colloidal silicon dioxide, croscarmellose sodium, dibasic calcium phosphate anhydrous, magnesium stearate, microcrystalline cellulose, talc, and Opadry(R) II pink 85F14289. Opadry pink is used for purposes of coating and contains the following: FD&C Red # 40, polyethylene glycol 3350, polyvinyl alcohol, talc, and titanium dioxide."
So, in other words, the formulation of the generic tranylcypromine clearly is not exactly the same as that of the brand-name Parnate, but both the GSK and Par Pharmaceutical versions of Parnate/tranylcypromine have film coatings. I have read a few (three or four) anecdotal reports on this board and elsewhere suggesting that the efficacy of the generic is comparable to that of the name-brand product.
> --- GloLD Shield slighty small,comes in a small canister like case,small is underused,i mean tiny,cute even,top pops off.Effective,imprinting on the tab,tabs do seem to at times break apart so they do need care in handling,otherwise fine.
The Goldshield product that I've been taking (the generic "Tranylcypromine" that's marketed in the U.K.) in combination with SAM-e is consistent with the product that you described above. Each bottle contains 28 tablets and a cylindrical object that is apparently filled with silica gel. The text "FW 251" is imprinted on each tablet.
According to the patient information leaflet that comes with each bottle of tranylcypromine (Goldshield Pharmaceuticals Ltd, 2001), the tablets contain the following inactive ingredients: sucrose, maize starch, calcium sulphate dihydrate, sodium carboxymethyl cellulose (E466), magnesium stearate (E572), gelatin, dioctyl sodium sulphosuccinate, talc (E553[b]), pharmaceutical glaze, kaolin (E559), calcium carbonate (E170), ethyl cellulose, arabic gum (acacia E414), carmoisine (E122), ponceau 4R (E124), titanium dioxide (E171), carnauba wax, and edible black ink.
Pharmaceutical glaze, also known as "shellac," is water-insoluble at low pH levels and water-soluble at high pH levels, and it's used as an enteric coating agent (Pearnchob et al., 2004). It was an inactive ingredient in the "old" Nardil (Parke-Davis Division of Pfizer Inc., 2002), but not the "new" Nardil (Parke-Davis Division of Pfizer Inc., 2003).
> All of the above work,the last i believed might have worked better,more stimulative but never had the chance to totaly isolate it.
I personally found Goldshield's U.K. version of tranylcypromine to be more stimulating than the GlaxoSmithKline version of Parnate. Specifically, the midday fatigue that literally knocked me out every afternoon while I was taking 20 mg/day of the GSK Parnate seemed to be completely nonexistent while I was taking 20 mg/day of Goldshield's U.K. product.
Of course, it is possible that some individuals might not notice as dramatic of a difference between the two versions of Parnate/tranylcypromine as I did. I also can't say what kind of difference I might have felt between the two versions of the drug if I were taking it at a higher dose.
> *********Now heres the bomb shell **********
>
>
> The last known parnate i seen says it is from goldshield,HOWEVER unlike any of the U.S based ones,OR THE MENTIONED GOLDSHIELD above,this one differed.
>
>
> FIRST in came in a box,within blistered packs.
>
> SECOND it had no imprinting on the tab,none.
>
> THIRD Thin,i mean thin,thin as a button on a shirt.
>
> FOURTH in my case made me very sick,interacted with almost everything i normaly take with my usual parnate,i.e klonopin,nuerontion,etc.
>
> It did this in a major way.In addition it did not help.
>
> So im left to wonder if this last brand i had,which i also waited a long time for,was some sort of,well i dont even know.I'm wondering if the Goldshield product that you described above might be the version of Parnate/tranylcypromine that the company markets in Australia, New Zealand, or perhaps elsewhere. Unlike the version of the the drug that is marketed in the U.K., Parnate is marketed under its brand name in Australia and, and the pack size is 50, not 28 (Goldshield Pharmaceuticals Ltd., n.d.). Did the blister packs that you received contain 50 tablets each? If so, you might have been taking the version of the drug that's marketed in Australia or New Zealand.
Interestingly, I also noticed on Goldshield's Web site that they market Parnate capsules (not tablets) in Ireland and the Netherlands, so I wouldn't be surprised if the formulation of the Goldshield product that you described above (wherever it came from) were indeed different from the first Goldshield product that you described (which I'm guessing is the U.K. version). Of course, I can only speculate as to whether or not the versions of the Goldshield Parnate/tranylcypromine that are marketed in certain countries are more effective than the versions that are marketed in other countries. However, considering that Goldshield manufactures Parnate/tranylcypromine as tablets for some countries and as capsules for others, it would make sense that the coating and/or dissolution/degradation properties of the drug might too differ from one country to the next -- possibly to the extent that there might be some variations in effectiveness.
Of course, I'm just speculating here. As far as I know, the version of Parnate/tranylcypromine that's marketed in the U.K. might not be significantly different from the versions of the drug that it markets elsewhere -- at least in terms of the drug's ingredients, type of coating, and dissolution/degradation properties. Judging from what you've written, though, it would be my guess that your responses to the two different types of the Goldshield Parnate probably differed because of formulation differences between the two products.
But then again, that's just a guess.
Tomatheus
==
REFERENCES
Goldshield Pharmaceuticals Ltd. (2001). Patient information leaflet on 'Tranylcypromine' tablets, 10mg. (Available from Goldshield Pharmaceuticals Ltd.; NLA Tower, Croydon, Surrey CRO OXT. U.K.).
Goldshield Pharmaceuticals Ltd. (n.d.). Goldshield Pharmaceuticals Australasia. Retrieved January 12, 2007, from the Goldshield Pharmaceuticals Ltd Web site, http://www.goldshield-pharmaceuticals.com/Australasia.htm
Par Pharmaceutical Companies, Inc. (2006). Tranylcypromine sulfate tablets 10 mg, prescribing information. (Available from Par Pharmaceutical Companies, Inc.; Spring Valley, NY 10977; United States).
Parke-Davis Division of Pfizer Inc. (2002). Nardil(R) (Phenelzine sulfate tablets, USP), labeling information. Retrieved January 13, 2006, from the U.S. Food and Drug Administration's Web site: http://www.fda.gov/cder/foi/label/2002/11909slr030lbl.pdf
Parke-Davis Division of Pfizer Inc. (2003). Nardil(R) (Phenelzine sulfate tablets, USP), labeling information. Retrieved January 13, 2006, from the U.S. Food and Drug Administration's Web site: http://www.fda.gov/cder/foi/label/2003/11909slr033_nardil_lbl.pdf
Pearnchob, N., Dashevsky, A. & Bodmeier, R. (2004). Improvement in the distintegration of shellac-coated soft gelatin capsules in simulated intestinal fluid. Journal of Controlled Release, 94, 313-321.
Thomson PDR. (2007). Physicians' desk referencde (61st ed.). Montvale, NJ: Author.
poster:Tomatheus
thread:721008
URL: http://www.dr-bob.org/babble/20070107/msgs/721548.html