Posted by tessellated on January 5, 2007, at 14:56:11
In reply to Re: General Maoi Tip-SLS » tessellated, posted by SLS on January 5, 2007, at 6:30:59
scott,
re: my paranoi/mania, i believe was from parnate withdrawl/insomnia/and a very brutal heartbreak. i decided it would qualify as a "brief psychosis" according to dsm. i don't agree that when AD's trigger mania in folks they should be labled bipolar. it's obviously a grey scale, and never in my life until parnate had i experienced a manic break.i tried the benzo/parnate option, but never felt the full cognitive effect of parnate until after 14-20hs of dosing. i always was wide awake in the middle of the night and really didn't wanna pull an elvis, so i just didn't sleep for 36, then slept soundly from sheer exhaustion.
perhaps its a little too potent for me. much like a more healthy amphetamine at 100mg/and higher. the creative drive is ever so tempting. the rush of purpose, drive, etc. but the affect on (i think) the dopaminergic system, is what brought on the paranoia, etc over a prolonged period. i probably could have just cut back dosage. dunno, it just sort of runs away with me. frustrating...
yeah, check out milnacipran's structure on biopsychiatry vs. parnate.
http://biopsychiatry.com/milnacipran/index.html
http://biopsychiatry.com/tranylcypromine/index.htmlfast acting. seems like i can feel that NE blocking in about an hour.
nardil, i've been told is the "shot-gun" MAOI. since you've got some supposed reuptake inhibition going on w/GABA and 5HT plus nortriptyline's boosted NE/5HT, and then abilify's curious agonist/antagonist mix, i don't think there's anyway to figure out what the heck it's gonna do. not to mention the tendency of the other meds to simply slow (moderate?) neural excitation. dunno, i've wondered about a valproate/parnate combination...
sound's like shooting pinballs around a rubber room and trying to ascertain their end position.
the issue i'm realizing about myself, and one that i think is hard to factor in is how our neurons adapt over extended periods after exposure to drugs, neural plasticity, receptor sensitivity, etc. where is baseline?
i've seen myself run into polypharmacy problems by moving too fast from one med or SE to another, swinging around like a monkey on the merry-go-round.
not that i'm turning herbalist/homeopathic, but i do feel that some of my worst/darkest/scariest states were in themselves unintentionally medically produced.
the endogenous/exogenous delineation is a problematic reductivist polemic.
i started on meds due to a exaggerated reaction to: death, trauma, and loss. the meds did allow a certain remarkable semi-sustainable functionality, but as well caused some form of neurological dependancy/personality shift which then fogged my sense of self, as a bio-chemoelectrically conscious being.
ultimately this is a chicken in the egg contemplation and i'm picken the chicken.
a minimalist "less is more" approach.p.s: serotonin syndrome is a tricky diagnosis. particularly with the ion pump and gaba activity. i got cold and rigid. the anticonvulsants might decrease that affect to good or bad effect; i.e. mask the symptoms. dunno?
strange note: the MAOI's greatest fear is the hypertensive crisis, i only experienced the hypotensive state. i never understood that.
cheers,
l8
>
> nortriptyline 100mg
> Nardil 60mg
> Lamictal 150mg
> Topamax 100mg
> Abilify 10mg
>
>
> I restarted Nardil. I'm hoping that I'm not developing a mild serotonin syndrome when combined with nortriptyline.
>
>
> - Scott
poster:tessellated
thread:718137
URL: http://www.dr-bob.org/babble/20070101/msgs/719633.html