Posted by linkadge on November 26, 2006, at 21:01:02
In reply to Re: FYI...Thought this was sad and funny » linkadge, posted by Racer on November 26, 2006, at 19:50:33
>There's an increase in extracellular dopamine, >of course, because of the DAT blockade. That >leads to a downregulation in the 5HT2c >receptors, which is the serotinergic effect.
I suppose. Although, if like you mention below, downregulation of 5-ht2c results in more dopamine release, this would additionally point to the dopaminergic effects of ritalin.
>Then again, that fits with other studies showing >that SSRIs work by downregulation of the 5HT2c >receptors, which reduces the inhibition of >dopamine release...I don't know if I'd say work by this mechanism. Consider it this way. Even if the drug downregulates 5-ht2c, thats not to say you have more dopamine released, just that the brain is trying to compensate for the SSRI induced inhibition on dopamine release.
So, you may have downregualted 5-ht2c, which will result in more dopamine release only when drug levels drop. So long as drug levels remain high, you have excessive stimulation of 5-ht2c. So, *excessive stimulation* of a *dowregulated receptor*, may just result in normal dopamine release.
Linkadge
poster:linkadge
thread:707054
URL: http://www.dr-bob.org/babble/20061123/msgs/707653.html