Posted by Racer on November 26, 2006, at 19:50:33
In reply to Re: FYI...Thought this was sad and funny, posted by linkadge on November 25, 2006, at 14:55:17
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> Methylphenidate has negligable effect on the serotonin reuptake pump, but significant affinity for the dopamine reuptake pump. So if it affects serotonin, I don't know how.
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> Linkadge
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>There's an increase in extracellular dopamine, of course, because of the DAT blockade. That leads to a downregulation in the 5HT2c receptors, which is the serotinergic effect.
Of course, that's also based on limited studies.
Then again, that fits with other studies showing that SSRIs work by downregulation of the 5HT2c receptors, which reduces the inhibition of dopamine release...
poster:Racer
thread:707054
URL: http://www.dr-bob.org/babble/20061123/msgs/707628.html