Posted by linkadge on November 26, 2006, at 13:44:49
In reply to Re: SSRIs and Dopamine, whats the verdict?, posted by Morhoun on November 26, 2006, at 12:53:15
This doesn't say that SSRI's increase dopamine at all. At it says is that when you artificilly increase serotonin with SSRI's, the brain start to try and look for other ways to metabolize the unnaturally high levels of the neurotransmitter.
>Dopamine transporters have a low affinity for >serotonin, but the higher serotonin levels >result in its uptake by the dopamine >transporters, found the scientists.
In this case, the dopamine transporter starts to work to mop up serotonin. Ie to try and counteract the SSRI.
>As a result, the normal dopamine-triggered >firing from such neurons, in essence, launches >two different types of neuronal ammunition, >causing "cosignaling."
This doesn't mean that the drug triggers dopamine signalling, it means that now normal dopaminergic responces result in serotonergic responces as well.
This kind of research just points to the havoc that SSRI's cause.
Linkadge
poster:linkadge
thread:706645
URL: http://www.dr-bob.org/babble/20061123/msgs/707438.html