Posted by linkadge on November 24, 2006, at 20:45:15
In reply to Re: SSRIs and Dopamine, whats the verdict? » Morhoun, posted by ace on November 24, 2006, at 20:19:14
I would tend to agree with ACE. There is a substantial amount of literatue supporting the theory that SSRI's supress many normal dopaminergically mediated processes. From drive to sexual function. For certain types of depression, SSRI therapy often makes the situation worse.
There are some exceptions being prozac and zoloft which which *may* posess additional dopamine preserving properties. In the end though, the effect of serotonin reuptake likely supercedes this to a certain extent, and produces an overall damepning of dopamienrgic function.
I've never seen an literature which shows that SSRI's increase dopamine to any significant extent, except fluoxetine. Even the dopaminergic effects of fluoxetine however are restricted to the frontal cortex.
Linkadge
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