Posted by SLS on November 22, 2006, at 4:42:58
I have been on Nardil for two weeks. I have been at 45mg for one week. I am convinced that Nardil or its metabolites have an acute beneficial effect that is independent of MAO inhibition. This includes mood brightening and pro-social effects. I felt these within the first week at a dosage of 30mg. I believe this is to be too low a dosage and too soon for there to be sufficient enzyme inhibition to exert an antidepressant effect. In the past, I have demonstrated a need to be within the dosage range of 60-75mg to maintain a response. Additionally, when I was responding well to Nardil many years ago, I would experience an energizing effect within an hour of each dose. I take this to be further evidence of an acute pharmacological effect of some sort separate from MAO inhibition.
I am still suffering from an exacerbation of my depression that is residual from my taking Lyrica. It has been almost two months since I discontinued that drug. I am much recovered, but I still experience episodes of acute worsenings. They hit me in waves. Lately, though, they have not lasted for more than a day. Two days ago, the wave lasted for about 8 hours.
I am hopeful that Nardil might produce a greater improvement now than it has over the last 15 years because of how it is being combined with other medication. It will be the first time that it will be used in conjunction with nortriptyline, Topamax, and Abilify.
Currently:
Nardil 60mg
nortriptyline 100mg
Lamictal 150mg
Topamax 100mg
Abilify 10mg
- Scott
poster:SLS
thread:706075
URL: http://www.dr-bob.org/babble/20061117/msgs/706075.html