Posted by zeugma on November 1, 2006, at 8:25:28
In reply to Re: Trying Emsam., posted by linkadge on October 31, 2006, at 6:47:34
> Regional dampening of glutamatergic function. Its an interesting theory, but it doesn't explain everything.
>
> For instance, would NMDA receptor modulation occur with all classes of antidepressants, both activating and calming? Aren't certain disorders like ADHD actually linked to low glutamatergic function. In which case, would an activating AD like bupropion, with utility in ADHD have the same downstream effect?
>I think the NMDA theorists claim that reduced NMDA activity results in increased AMPA activity, and there are studies that show that AMPA positive modulators have antidepressant effects (in animal models).Positive AMPA modulators have also been proposed for ADHD.
-z
>
poster:zeugma
thread:698340
URL: http://www.dr-bob.org/babble/20061028/msgs/699546.html