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Re: Sorry for the interruption. » SLS

Posted by zeugma on September 21, 2006, at 7:36:53

In reply to Sorry for the interruption. » zeugma, posted by SLS on September 20, 2006, at 21:49:06

hi Scott,

I appreciated that you posted that to me a couple of months ago. Unfortunately I was not able to express this because I was blocked for the summer for making a tactless remark about the FDA(no doubt the feelings of partisans of current FDA policy were immensely cheered by my enforced absence- the cause of the gretaer good etc.)

I was disappointed that sibutramine did not work out for you. I think that maybe the muddiness you felt was a dopaminergic effect. Right now I am entertaining the thought that side effects/strange reactions are more prevalent when stimulation is applied to circuitry that is particularly broken down.

The anticataleptic effect of sibutramine is probably attributable to its NE/5HT reuptake properties. It would be interesting to try, although the last thing i need is a drug that promotes weight loss. from the little I've been able to find out about its pharmacology, it appears to be a very clean drug.

-z


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