Posted by blueberry on September 20, 2006, at 16:22:44
"Methylphenidate sensitization is modulated by valproate".
Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, PO Box 20708, Houston, TX 77225, USA.
Repeated administration of psychostimulants such as amphetamine, cocaine, and methylphenidate has been shown to induce behavioral sensitization. Sodium valproate, an anticonvulsant agent that enhances GABA activity, and dizocilpine (MK-801), a non-competitive NMDA receptor antagonist, can block the sensitization elicited by psychostimulants.What does this mean? When they say depakote blocks the sensitization to repeated stimulants, does that mean it prevents getting immune to the effects of the repeated stimulants, or does it mean it just outright blocks the effects of the stimulants?
There were several abstracts on this subject and they all kind of gave me the impression that stimulants work smoother without developing tolerance when in the presence of depakote. But it all depends on what they mean by "behavioral sensitization", which is what I am hoping all you experts out there can help me with.
poster:blueberry
thread:687712
URL: http://www.dr-bob.org/babble/20060919/msgs/687712.html