Posted by pseudoname on July 2, 2006, at 10:58:03
In reply to Damaged DNA:Depression's hidden culprit??, posted by capricorn on July 2, 2006, at 2:51:17
Thanks very much for posting this, capricorn.
To sum it up for the click-shy: Problems with other chemicals around our DNA molecules may prevent DNA segments from giving instructions for the creation of brain-derived neurotropic factor (BDNF). The reduced BDNF levels may then result in depression symptoms. An antidepressant like imipramine partially opens the DNA back up so that it can produce more BDNF again.
Neato!
But there's much I don't get about it. Why does it affect just BDNF creation? Why doesn't the hypermethylation shut down protein production generally?
poster:pseudoname
thread:663417
URL: http://www.dr-bob.org/babble/20060701/msgs/663512.html