Posted by pseudoname on June 18, 2006, at 20:43:58
In reply to Re: again: buprenorphine is different » pseudoname, posted by Declan on June 18, 2006, at 18:52:00
> We know the long term effects of natural opiates.
What are they? By long-term, you mean 5, 10 years?
> PN, what do you know about the long term effects of bupe?
AFAIK, there's no published data on long-term bupe use at the doses I've been taking it. The studies with opiate addicts are at 8 mg/day or more. (That's also the case with the admittedly few personal accounts I've seen on other forums, which have mostly seemed to be NON-NAIVE and comorbid users.)
And, as with SSRI studies, "long-term" for bupe researchers seems to mean 6 months to a year! It's frustrating. No one can make good projections on the basis of that sort of data.
I would really like to know what happened to the people in Bodkins' 1995 study. Actually, I seriously think I'll contact him about that.
> How long has it been around?
First synthesized in 1969 and used clinically as a parenteral analgesic in 1978. The addiction treatment started in the mid-1990s in Europe, I think.
The first report on its use in depression was published in 1982; the second in 1995; the third in 2005. This is a very slow collection of data.
> I mean, if it was helping *me*, I'd place a bet that it wouldn't be *that* good long term
[Bursts of laughter]
Always nice to hear a word of encouragement.
[More laughter ;-) ]
> OTOH I have had friends say 'I don't want to feel clearer. Why do you think I take opiates in the first place?'
You people sure have a lot more friends than I do.
poster:pseudoname
thread:651514
URL: http://www.dr-bob.org/babble/20060617/msgs/658503.html