Posted by linkadge on June 18, 2006, at 19:16:32
In reply to Re: Opiate trap!, posted by flmm on June 18, 2006, at 14:34:10
Opiates are multi mechanism drugs. They will increase dopamine in the pleasure centres of the brain, but their painkilling properites are independant of this.
It is hard to know. I think there is a tendancy for those who's depression is not ameliorated by opiates to blame the opiates for increasing depression, while this may not be the case.
Some people may geting relief from this surge of activity in the pleasure centres of the brain, but not from other properties of the opiate.
It would be interesting to see, if the antidepressant effect is maintained with coadministration of an agent that blocks the increase in dopamine in the neucleus accumbens.
Linkadge
poster:linkadge
thread:651514
URL: http://www.dr-bob.org/babble/20060617/msgs/658468.html