Posted by blueberry on May 25, 2006, at 18:46:40
In reply to Amisulpride..??, posted by willyee on May 25, 2006, at 11:36:22
I took amisulpride for a few months with prozac, and have tried it several times since then. The same pattern always happens...
It starts with a definite stimulant effect. The first couple days especially. Then tolerance to the dopamine develops rapidly, and the stimulation fades. Then it feels like it isn't doing anything at all. Then at about 3 or 4 weeks, the antidepressant and anti-anxiety and prosocial stuff kicks in nicely.
But as was mentioned, the increased prolactin can be a real problem. I had the worst sexual side effects on amisulpride than anything. Bad. That has always been the reason I stopped it. Had I known about the clinical studies, I would have added bromocriptine to it to normalize prolactin without affecting the therapeutic benefits.
I started at 25mg, went up to 50mg, tested the 75mg and 100mg range, but liked the 25mg to 50mg range better. It's weird with this one how less is more. But like all antidepressants, it does take time. The initial stimulation will fade quickly and then you just have to hang in there and wait.
poster:blueberry
thread:648363
URL: http://www.dr-bob.org/babble/20060525/msgs/648563.html