Posted by yxibow on May 17, 2006, at 17:06:13
In reply to Larry, let me ask you this, posted by UgottaHaveHOPE on May 17, 2006, at 12:37:04
> So I took 25mg of Seroquel for eight months and it worked great. Then I had a personal issue that got me upset, and 25mg wouldn't calm me down any longer. So I went up to 300mg ... and it is making me sleep, but I am not as sedated as I was at 25mg.
>
> My question is this: Is my brain now used to 25mg and will no longer be able to go back and use this level with any effectiveness? Or will I have to keep going up in Seroquel? And is there a point where my receptors are used to any level of Seroquel, therefore it is not effective at all? What happens then? Do I have to take another drug with it to make it work?
>
> Thanks for your terrific inputs. Please explain in laymen's terms. Thanks, Michael
You might need adjunctive medication such as Lunesta to sleep if you actually gain full "immunity" to the effects at H1, which is unlikely as Seroquel is still at least somewhat soporific to most people by the time you get to the dose you're at. It is probably true as noted that if you went down but not completely off, that you might need 50mg as suggested, but that's just trial and error. If you completely flushed Seroquel out of your system say for a few weeks or a month, the 25mg would probably again cause sleep benefits, most likely, but that varies by the individual.I do adjunctively take Ambien, but its probably more to stay asleep than to go to sleep -- Seroquel at 100/900 split dose (bedtime) will still make me go to sleep. Seroquel also decreases my blood pressure during the day in general which follows since the effects at H1 contribute to orthostatic hypotension (low blood pressure).
-- Jay
poster:yxibow
thread:644933
URL: http://www.dr-bob.org/babble/20060515/msgs/645233.html