Posted by yxibow on May 17, 2006, at 0:48:31
In reply to Re: Does taking MORE Seroquel make you LESS sedated?, posted by bipolarspectrum on May 16, 2006, at 20:57:45
> Hi,
> I've heard quite a few people say the exact same thing on here many times.... however, with my experience, the opposite happened... I think u should be willing to be flexible in ur dosing and find that which is best for you...
> bps
>
> > Thats what I have heard some people on here say. I took 25mg only for eight months and it made me very tired. Then I had some financial issues, got really jacked up, am taking 300mg per day and dont seem to be as tired. Can someone explain this to me?
You're one of the small population that adjusts to the H1 (antihistamine) effect of Seroquel. Consider yourself lucky! I have never adjusted completely to it. I am trying a 100/900 split dosing and sometimes I can adjust to the 100, sometimes it knocks me out. I can tell you that 900 definately is soporific, no matter how long I've taken it. But its probably true that the total 1000mg of Seroquel that I take would knock out a completely Seroquel-naive person pretty quickly. It's a matter of when I take the bulk of the dose at night -- I find that its H1 effects wear off after 2 half lives, which is about 12 hours, or 3 more than I typically sleep. So I have to arrange to take a dose as early as possible if I need to get up earlier.
poster:yxibow
thread:644933
URL: http://www.dr-bob.org/babble/20060515/msgs/645032.html