Posted by linkadge on May 2, 2006, at 18:11:15
In reply to Re: missing link » SLS, posted by zeugma on May 2, 2006, at 17:14:21
I like the endocannabanoid deficiancy theory.
There are drugs like anandamide reuptake inhibitors in the pipelines. Anandamide binds to 5-ht1a like buspar, but it also antagonizes 5-ht2a. It acts at other receptor systems too. It has strong anxiolitic properties, and I believe it is neurotrophic.
In animal models of depression 5-ht1a agonists seem to be effective for both depression and anxiety.
I'd hate to think that the theraputic effect of SSRI's is reduced to their agonism at 5-ht1a, otherwise we're hitting a lot more receptors than necessary.
Yeah, thats a good question, as to how different serotonin genes would affect responces to SSRI's vs. tianeptine.
The interesting thing about tianeptine, is that it displays neuroprotective capacity far beyond the effects of SSRI's. Tianeptine seems to have a strong ability to block stress induced hipppocampal morphological (sp.) changes.
Linkadge
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URL: http://www.dr-bob.org/babble/20060429/msgs/639372.html