Posted by linkadge on May 2, 2006, at 16:09:31
In reply to Re: Animal models of psychiatric illness, posted by zeugma on May 2, 2006, at 5:42:14
Thats tue. You're right rats don't care. They don't even know they're getting drugs.
I guess the problem is that even though the rat may start to act more "normally" we still don't really know how they feel inside.
Kind of like with the SSRI's with me. I know that I may have been eating better, and sleeping a bit better, but thats a long way from actually reporting feeling better.
Another big flaw I see is that we don't test the drugs on animals for long enough. So a drug can keep an animal swimming a little longer in the short term, but how do we know that effect will last into the long term.
I'm not saying SSRI's don't work for certain people, I just don't think they have a terrably profound antidepressant effect overall.
I don't want to say cause I don't really know, but I have suspicion that there are a lot of good antidepressants like amineptine that get pulled because they have abuse potential, even though they *may* be arguably more reliable, fast acting, and robust.
Linkadge
poster:linkadge
thread:638491
URL: http://www.dr-bob.org/babble/20060429/msgs/639316.html