Posted by SLS on April 10, 2006, at 6:35:34
In reply to Re: Amisulpride Sucks So Far.... » SLS, posted by TomG on April 9, 2006, at 21:45:29
> Have you known anyone to combine pramipexole with amisulpride?
No, I haven't. It is an interesting proposition, though.
> Should the amisulpride fail on its own I thought it a good place to start for augmenting agents. That or a stimulant. I've got a lonley bottle of modafinil in my medicine drawer too.
You never know what's going to do what. Linkadge might have some insight into how the drug pairings might interact.
Ideally, one might profit from combining amisulpride with a dopamine reuptake inhibitor like amineptine. Unfortunately, it is no longer available. Ritalin works as a DA reuptake inhibitor, but I'm not sure it exerts this action where it is most needed.
Modafinil is a drug with multiple actions. It does not seem to affect directly NE or DA neurotransmission. However, it does stimulate the release of glutamate in the thalamus, which then stimulates the release of DA in the nucleus accumbens.
Amphetamine acts primarily as a DA and NE releaser, although it also inhibits reuptake. I'd be inclined to try this first. The amisulpride would induce an increase in the synthesis of DA with the amphetamine inducing its release. It's just a guess, though.
I would also consider adding selegiline somewhere in there.
- Scott
poster:SLS
thread:630962
URL: http://www.dr-bob.org/babble/20060408/msgs/631316.html