Posted by SLS on April 9, 2006, at 19:50:18
In reply to Re: Amisulpride Sucks So Far.... » SLS, posted by linkadge on April 9, 2006, at 19:32:51
> I wouldn't think there would be latency either. The rational for this drug strange/mixed. It would not need time to desensitize dopamine autoreceptors like perhaps a MAO-B inhibitor. Wasn't it thought to work as dopamine autoreceptor antgonist ?
>
> The other issue is that, it still is an antipsychotic. I think it has strong antagonistic affinity for D3 receptors (which are heavily located in the neucleus accumbens). So the net effect on dopaminergic neurotransmission, I don't know.Me neither.
I didn't know about the D3 antagonism. I wonder what would happen if one were to mix amisulpride with either pramipexole or ropinirole. I guess it would depend upon the relative binding affinities of each drug to the pre- and post- synaptic receptors. One would hope that amisulpride would be stronger at the presynaptic D2 and the agonists stronger at the postsynaptic D3.
- Scott
poster:SLS
thread:630962
URL: http://www.dr-bob.org/babble/20060408/msgs/631127.html