Posted by Michael Bell on March 12, 2006, at 3:26:41
In reply to Re: And that's the problem » Michael Bell, posted by ed_uk on March 11, 2006, at 13:17:42
Hey Ed,
Most Mao-A, which has more of an antidepressant than Mao-B, is found in the intestine, liver and gut area. Mao-B, on the other hand, like what deprenyl causes inhibition of at low doses, is found mainly in the brain (despite what the smart-drugs website claims). Nardil's main site of action is in the small intestine, NOT the brain.
> Hi M
>
> >Bioequivalency only discusses the absorption rate of the drug into the bloodstream, NOT the rate and completeness of the absorbtio at the site of action.
>
> Phenelzine exerts its antidepressant and anxiolytic efficacy by acting on the brain. Its 'site of action' is the brain, not the intestine.
>
> >However, what happens to the drug after it enters the bloodstream is not assessed.
>
> Excipients do not affect the pharmacological properties of a drug molecule once it reaches the blood stream.
>
> >The theory has always been that the new nardil is not being absorbed as well at the site of action of the drug.
>
> That doesn't make sense to me. Phenelzine's site of action is the brain. The excipients do not influence the ease at which the drug can cross the blood-brain barrier.
> Regards
>
> Ed
>
>
>
>
poster:Michael Bell
thread:617166
URL: http://www.dr-bob.org/babble/20060310/msgs/619219.html