Posted by ed_uk on March 11, 2006, at 13:17:42
In reply to And that's the problem » ed_uk, posted by Michael Bell on March 11, 2006, at 11:41:38
Hi M
>Bioequivalency only discusses the absorption rate of the drug into the bloodstream, NOT the rate and completeness of the absorbtio at the site of action.
Phenelzine exerts its antidepressant and anxiolytic efficacy by acting on the brain. Its 'site of action' is the brain, not the intestine.
>However, what happens to the drug after it enters the bloodstream is not assessed.
Excipients do not affect the pharmacological properties of a drug molecule once it reaches the blood stream.
>The theory has always been that the new nardil is not being absorbed as well at the site of action of the drug.
That doesn't make sense to me. Phenelzine's site of action is the brain. The excipients do not influence the ease at which the drug can cross the blood-brain barrier.
Regards
Ed
poster:ed_uk
thread:617166
URL: http://www.dr-bob.org/babble/20060310/msgs/618884.html