Posted by Chairman_MAO on March 11, 2006, at 17:51:18
In reply to Re: Many people fear MAOI's...., posted by bassman on March 10, 2006, at 17:55:49
I also forgot to add that Wellbutrin is an analog of Tenuate (diethylpropion), an aminoketone diet pill and psychostimulant. The company invested money, so they had to find a use for the drug somehow. It is nothing more than a dysphoric, weak stimulant. Moreover, at the doses used clinically, it only blocks the DAT about 20%, i.e. it's hardly a dopaminergic drug at all. The primary mechanism of its "antidepressant efficacy" is probably enhanced noradrenaline release. Hydroxybupropion is also an NE uptake inhibitior.
Bupropion's affinity for the DAT is in the MILLIMOLAR range, IIRC (negligable activity).The bottom line is that bupropion certainly wasn't "directed" toward anything any more than amphetamine was "directed" toward dopaminergic neurons when it was first synthesized in 1887.
poster:Chairman_MAO
thread:618332
URL: http://www.dr-bob.org/babble/20060310/msgs/618998.html