Posted by TylerJ on March 11, 2006, at 14:35:57
In reply to Re: Many people fear MAOI's...., posted by vainamoinen on March 10, 2006, at 17:04:58
> Any speculation as to why the MAOI's work so much better than the SSRI's?
>
> Is it because they act significantly on dopamine whereas most other AD's work on serotonin, or norepinephrine, but only to a lesser extent if at all on dopamine?
MAO (Monoamine Oxidase)destroys many neurotransmitters. MAOI antidepressants (e.g.,Nardil, Parnate. EMSAM) inhibit MAO, thus prolonging the life of the neurotransmitters-increasing neurol flow of noreadrenaline, dopamine, serotonin, acetylcholine, and GABA.
SSRI's bock serotonin reuptake into presynaptic nerve terminals, leading to enhanced serotonergic neurotransmission.
I think I'll go with the MAOI for obvious reasons. :)Tyler
poster:TylerJ
thread:618332
URL: http://www.dr-bob.org/babble/20060310/msgs/618924.html