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Re: provigil discussion

Posted by mike99 on February 26, 2006, at 15:28:14

In reply to Re: provigil discussion, posted by SLS on February 26, 2006, at 9:11:37

>>Losartan might be an ideal drug as it would also help mitigate the increase in blood pressure seen with modafinil. It would help reduce the effects of the excess plasma NE that modafinil is capable of producing. It should accomplish this by preventing the stimulation of peripheral NE alpha-1 receptors by endogenous NE.

Hey Scott,

Thanks for the info. Please correct me if I'm mistaken, but I believe losartin is an angiotensin II receptor antagonist.

And while this would lower blood pressure by preventing vasoconstriction and inhibiting aldosterone sectretion from the adrenals, it would not block peripheral NE alpha-1 receptors from endogenous NE (or epinephrine).

I think only an alpha-1 antagonist such as prazosin or a mixed alpha/beta blocker such as labetalol or carvedilol could do this.


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URL: http://www.dr-bob.org/babble/20060219/msgs/613508.html