Posted by blueberry on February 21, 2006, at 5:13:29
In reply to Re: Question for SLS, posted by SLS on February 20, 2006, at 21:17:59
Hi Scott,
Thanks for your thoughts. I will look forward to more followup if you think of something to add.
I get the hunch that with precursor loading the receptors sense so much concentration of neurotransmitters floating around that the release just slows way down. Not good for my mood, but great for silencing tinnitus.
How does wellbutrin effect me? Poorly. Worsened depression and a total loss of any motivation, just want to hide in a cave. And worsened tinnitus.
Remeron also depresses me. And increases tinnitus.
I tried nortriptyline a long time ago for just one week and don't remember much about it other than the drugged feeling and dry mouth.
> Hi Blueberry.
>
> First of all, I really do enjoy following your posts. You are very well informed and I respect your opinions.
>
> > Your thoughts please Scott on some brain mechanistics? ...
>
> I'm afraid that I don't have an immediately obvious answer for you regarding your experiences with precursor loading. I'll need to give it some more thought and a few peeks at Google. For now, I would say that *if* precursor loading resulted in an increase of synaptic neurotransmitter, there might be a lag time between the disappearance of neurotransmitter and the turning-off of presynaptic autoreceptors. This lag time might be responsible for the depression that follows as synthesis and release neurotransmitter remain inhibited.
>
> How does Wellbutrin affect you?
>
> Remeron and nortriptyline are other drugs that come to mind.
>
>
> - Scott
poster:blueberry
thread:611554
URL: http://www.dr-bob.org/babble/20060219/msgs/611635.html