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Re: Receptor selectivity as the next step?

Posted by linkadge on February 8, 2006, at 15:50:20

In reply to Re: Receptor selectivity as the next step?, posted by deniseuk on February 8, 2006, at 11:03:35

Sure, certain receptors are more concentrated in one area over another. 5-ht1a receptors have a high concentration in the hippocampus, if I am not mistaken.

I have the same problem as you Denise. For a short period of time SSRI's helped, but then things turned sour and I actually felt better off them. I still feel better off them. My brain thinks their toxic.

Another thing to consider is that brain chemistry can change. I was just reading how (in mice at least) The activity of the serotonin transporter changes over the course of a lifetime. So, you may be depressed for entirely different reasons than when you were at first.

Linadge



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