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Receptor selectivity as the next step?

Posted by Racer on February 6, 2006, at 14:12:14

It seems as though we have a lot of discussions here about which receptor types various drugs hit, and I wondered how many here think this should be the focus of new research, or if there are other areas of research that should be higher priority?

Personally, I think I'd like to see more research into the workings of the various receptor types, before research into the drugs that affect them. That way, they might learn more about the etiology of depression, or at least have an easier time creating drugs that maybe have a more benign side effect profile. Like an SRI that avoided activity at 5HT2c and 5HT3, to see if that actually did improve the GI and weight gain profiles. And, if they found that drugs HAVE to hit one of those receptor types, that might help them learn more about what causes depression in the first place, right?

Another thing I would like to see, though, is a better understanding on the part of psychiatrists in clinical practice, of just how much some side effects can impact our lives, and maybe a little more empathy towards us.

Of course, I'm speaking from my own bias, so take all that with a grain of salt.

What do the rest of you think?


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poster:Racer thread:606920
URL: http://www.dr-bob.org/babble/20060205/msgs/606920.html