Posted by Larry Hoover on December 1, 2005, at 23:20:41
In reply to How come Wellbutrin and Risperdal don't cancel, posted by Deneb on December 1, 2005, at 14:26:13
> How come Wellbutrin and Risperdal don't cancel each other out? Wellbutrin increases dopamine. Doesn't Risperdal decrease dopamine? My p-doc told me that Risperdal's actions are a lot more complicated. Can someone explain this to me? I'm guessing different types of dopamine receptors are involved in different parts of the brain. Am I right or wrong?
>
> DenebOh yes, you are right. It is very complicated.
Are you up for beginning to learn just how complicated? I know you're bright, and with your chemistry background, you should grasp a lot of this stuff.
Go to: http://kidb.cwru.edu/pdsp.php
Wait a second for the page to load, and then enter either of bupropion or risperidone in the box on the left titled "Test Ligand". Don't worry about the other boxes, just now. Submit query.
That will bring up lists of the various receptors and transporters affected by the drugs in question. Ki is loosely the drug's affinity for that receptor type, with the lower concentration value indicating higher affinity (i.e. 50% occupancy at lower ambient concentration).
I hope you are boggled, perhaps slightly overwhelmed. And this table does not show antagonism vs. agonism, and all that. Hotlinks to the articles in Pubmed (right column) may give you that info, but you usually have to go to the full-text. And then there's brain region, as you so correctly consider. And then there is the issue of genetic differences (polymorphisms).
Pharmacological treatment is an art.
Lar
poster:Larry Hoover
thread:584242
URL: http://www.dr-bob.org/babble/20051126/msgs/584382.html