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Re: Talk about...BuSpar

Posted by cache-monkey on November 21, 2005, at 12:49:27

In reply to Re: Talk about...BuSpar, posted by iforgotmypassword on November 21, 2005, at 3:28:35

> i think there may be some slight D2 antagonism with that drug. might be noticable when the dosage is upped.

In addition to D-2 antagonism, BuSpar's metabolite (1-PP) acts as an alpha-2 antagonist. Both could lead to unease. The D-2 antagonism would be like the traditional neuroleptic akathisia, while the alpha-2 antagonism could increase anxiety.


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URL: http://www.dr-bob.org/babble/20051119/msgs/580874.html