Posted by zeugma on October 30, 2005, at 22:28:01
In reply to Re: DPSP database clomipramine dopamine affinity, posted by iforgotmypassword on October 30, 2005, at 20:51:42
> are the tricyclics so directly descended from the early antipsychotics this? any other tricyclics with wierd surprises?>>
the tricyclics are all directly descended from the phenothiazines. In fact imipramine, amitriptyline, and clomipramine were all developed for neuroleptic potential; it was a major disappointment that they failed to work as neuroleptics. In the course of these trials an antidepressant effect was discerned, which was unexpected (although neuroleptics themselves may/may not have antidepressant effects; certainly unlike the TCA's this is not their most striking effect).
university is correct that ascendin has major potential to cause TD. But it is a cross pharmacologically between the TCA's and phenothiazines, not necessarily structurally (it has a close resemblance to loxapine). Clomipramine has been around for many years (though not in the U.S.), and i don't think it's considered a significant risk for TD. The hazard to watch out for is serotonin syndrome, when combined with an SSRI or especially a MAOI (this last is a strict contraindication).
the tricyclics are an especially well-studied group of drugs. i don't think weird surprises are a problem with them, although many do have considerable s/e.
clomipramine is chlorinated imipramine. If you add a sulfur atom to CMI's central ring, you have chlorpromazine.
the TCA's do have many resemblances to the early AP's, but some of these (e.g. antagonism of the 5ht 2 receptors) are considered potential antidepressant mechanisms.
-z
poster:zeugma
thread:573553
URL: http://www.dr-bob.org/babble/20051024/msgs/573624.html