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Re: MAO mice/man/anxiety/agression » linkadge

Posted by SLS on October 24, 2005, at 5:42:04

In reply to MAO mice/man/anxiety/agression, posted by linkadge on October 23, 2005, at 12:55:06

If one is born without MAO, they might develop a nervous system regulated using the other feedback loops available:

• reduced synthesis of amines
• reduced release of amines
• reduced storage of amines
• increased catabolism by COMT
• reduced postsynaptic receptor sensitivity
• increased presynaptic sensitivity
• increased numbers of GABA inhibitory
• increased numbers of glycine inhibitory
• modulation by varying peptide numbers
• modulation of second messengers and G-proteins

It makes sense that a viable equilibrium can be established during rest periods and without stimulation. However, external stimulation might create an abnormally larger burst of excitation because the remaining regulatory mechanisms cannot keep up with the momentary outflow of presynaptic neurotransmitter.

Just a guess.


- Scott

 

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URL: http://www.dr-bob.org/babble/20051024/msgs/571268.html