Posted by EERRIICC on September 23, 2005, at 20:21:31
In reply to Highest Serzone Dose You've Heard Of, posted by bigcat on September 23, 2005, at 13:46:11
Let me know if this works, as I am in a position similar to yours.
The 'dalhousie serotonin cocktail' for
treatment-resistant major depressive disorder
by
Dursun SM, Devarajan S, Kutcher S.
Department of Psychiatry,
Dalhousie University, Halifax, Nova Scotia, Canada.
sdursun@is.dal.ca
J Psychopharmacol 2001 Jun;15(2):136-8ABSTRACT
We describe the successful treatment of five patients with treatment-resistant major depressive disorder (TR-MDD) with a combination pharmacotherapy of pindolol, tryptophan and nefazodone. Five TR-MDD outpatients who had previously not responded to at least four different antidepressant medication trials were initiated on 300 mg/day of nefazodone, 7.5 mg/day of pindolol and 1 g/day of tryptophan. Pindolol doses remained the same throughout the 20 weeks, while tryptophan and nefazodone dosages were gradually increased to 8 g/day and 450 mg/day, respectively. The Hamilton Depression Rating Scale (HAM-D) was used to evaluate outcome. By week 4, all cases demonstrated at least 50% decrease in HAM-D scores. At the end of the trial, the group mean HAM-D score had significantly decreased from 26.8 (+/- 1.9) to 1.8 (+/- 0.8) (p < 0.001). No significant adverse effects were reported. These results suggest that if serotonin availability and release is further enhanced by tryptophan in the presence of nefazodone and pindolol, an antidepressant effect may be produced in patients who are otherwise treatment-resistant. Due to limited sample size, an open design and an 'unusually' high successful efficacy rate of this preliminary study, controlled studies are required to confirm the efficacy of this treatment strategy.Good Luck,
Eric
poster:EERRIICC
thread:558534
URL: http://www.dr-bob.org/babble/20050921/msgs/558698.html