Posted by blueberry on September 23, 2005, at 16:57:56
In reply to Highest Serzone Dose You've Heard Of, posted by bigcat on September 23, 2005, at 13:46:11
Serzone is tricky because it acts differently at different doses. I have a chart that shows its affinity at various blood levels. I remember myself when I tried it how I felt great at a certain dose, it kind of faded, the dose was increased, and then I got worse. It changes behavior at different doses. More isn't always better. It's a matter of finding that small window.
Depending on blood levels, these are the things it hits, from first to last, from lowest dose to highest...
5HT2A
NE a-1
Serotonin reuptake inhibition
Norepinephrine reuptake inhibition
NE a-2
Dopamine reuptake inhibition
Acetylcholine
Histamine...according to a psychiatrist chart of antidepressant affinities I found on the web.
Since you responded so well when first starting, maybe that was down in the 5ht2 and norepinephrine alpha-1 area.
I wonder how you would do with adrafinil...a mail order smart drug that enhances ne a-1 receptors as an agonist. It's a pretty tame med, and can take a few weeks to work, though the first day can feel stimulating. I tried it years ago and liked it a lot. Became interested in things, depression lifted, became more talkative. I took it I think for about 2 years along with prozac and remeron (in a way similar to serzone). One day I just decided I was fine and stopped it cold with no withdrawals whatsoever.
Anyway, I'm just thinking out loud. The clues from your good serzone experience say that somewhere in that chain of things it does is what you need. But again, different doses do different things.
I know it sounds weird, but maybe a lower dose might work better than a higher one. But since you asked, I do recall years ago of hearing people taking 800mg or more of it.
It's all so confusing. Wish I could help.
poster:blueberry
thread:558534
URL: http://www.dr-bob.org/babble/20050921/msgs/558610.html