Posted by Pfinstegg on September 12, 2005, at 23:22:09
In reply to Re: This neurogenesis theory doesn't ring true., posted by linkadge on September 12, 2005, at 17:47:43
Most of the agents that help depression do so by 1)activating the left frontal areas, 2)resetting the HPA axis at a lower level, and 3)allowing normal neurogenesis to resume in the hippocampus and probably other areas. One of the results of the neurogenesis, seen when SSRI's are used, is that more serotonin gets produced, and then stays around in the inter-cellular spaces.It seems as though most of the AD's initially do one or more of these things. TMS and ECT do all of them. I should put in the caveat that- not for everyone, and not permanently. I recently noticed an article which said that TMS, at regular intervals. plus the right AD is producing about a 70% remission rate. That's what has worked for me, so I have a bias in favor of it; I was so sorry to learn that it didn't work for you, Denise. And Link, what happened with your TMS machine? Do you think you used it too often?
As to why AD's poop out, I don't think this huge problem has been properly investigated yet. My own feeling- not based on very much hard evidence- is that the SSRIs and SNRIs cause an abnormal situation-too much serotonin in the brain, so that long-term, your dopamine drops, resulting in anhedonia, and the number of neurons producing serotonin drops, too, because the flood of serotonin makes one's brain think that these neurons are not needed. The drugs which seem to work best long-term are the MAOIs, which boost the amounts of serotonin, nor-epinephrine and dopamine about equally. I'm speculating that, with them, things are in better balance, and you don't lose any particular type of neuron. Of course, they're not so easy to take! Maybe the selegiline patch will work out well.
poster:Pfinstegg
thread:553151
URL: http://www.dr-bob.org/babble/20050909/msgs/554497.html