Posted by ed_uk on July 22, 2005, at 18:11:55
Just out of interest, has anyone ever taken tamoxifen (the breast cancer drug) to treat acute mania?
I noticed that tamoxifen hasn't been discussed much on babble before, just a couple of threads a few years ago.
J Clin Psychiatry. 1999;60 Suppl 2:27-39; discussion 40-1, 113-6. Related Articles, Links
Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications.
Manji HK, Bebchuk JM, Moore GJ, Glitz D, Hasanat KA, Chen G.
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Mich 48201, USA.
In an attempt to find the key to reducing the excessive morbidity and mortality seen with mood disorders, our laboratory has been extensively investigating lithium's mechanisms of action in an integrated series of clinical and preclinical studies. We have found that the chronic administration of the 2 structurally highly dissimilar agents, lithium and valproate, brings about a strikingly similar reduction in protein kinase C (PKC) alpha and epsilon isozymes in rat frontal cortex and hippocampus. In view of PKC's critical role in regulating neuronal excitability and neurotransmitter release, we have postulated that PKC inhibition may have antimanic efficacy. In a small study, we have found that tamoxifen (which, in addition to its estrogen receptor blockade, is also a PKC inhibitor) has marked antimanic efficacy. These exciting preliminary results suggest that PKC inhibitors may represent a novel class of improved therapeutic agents for bipolar disorder, and this is under further investigation............................
~Ed
poster:ed_uk
thread:531784
URL: http://www.dr-bob.org/babble/20050718/msgs/531784.html