Posted by TamaraJ on July 13, 2005, at 12:30:24
In reply to Re: Question for Scott (if you have time) » TamaraJ, posted by SLS on July 13, 2005, at 9:48:14
> What you can do as an experiment is take the Wellbutrin when you first wake up and take your Zoloft 6-8 hours later and try to identify which is creating the fatigue that comes over you during those first few hours post dose. Of course, you need to be sure that you don't normally get fatigued during the time of day that comes 6-8 hours after wakening. If in doubt, just switch the order and compare. I recently used this type of an experiment to identify that someone was being underdosed with their antidepressant.
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-- That sounds like a good idea. Tomorrow, I will take the Wellbutrin in the morning, as usual, and the Zoloft about 2 or 3 in the afternoon. I will do that for two days to see if it makes a difference in the amount of fatigue. If not, then I will try the reverse for a couple of days.
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> You've had some very talented minds commenting on your condition. It seems that there is a consensus among us that using nortriptyline in your next combination is worthy of consideration. I would go with the Zoloft + nortriptyline alternative.
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-- Yes, I certainly have, and I appreciate the input and advice from you incredibly wise and knowledgeable people. I agree that the Zoloft + nortriptylne would be the way to go next. I came across a couple of abstracts today, one of which said that of all the SSRIs, Zoloft was the only one that has demonstrated efficacy in treating melancholic depression (I don't think it was a particularly big sample though), and others that indicate that the TCAs, particularly nortriptyline in the case of women and those over 40 (if I am remembering right), appear most effective for melancholic depression. So, that sounds pretty compelling, on paper at least.-- I guess if I went for that combo, I would go with either 50mg or 75mg of Zoloft and 50mg or 75mg of Nortriptyline, right? Is there any danger of cardio side effects at those doses, particularly considering that, as I understand it, SSRIs potentiate TCAs?
Thanks again, ScottTamara
poster:TamaraJ
thread:525731
URL: http://www.dr-bob.org/babble/20050713/msgs/527120.html