Posted by TamaraJ on July 12, 2005, at 18:14:25
In reply to Re: Question for Scott (if you have time) » TamaraJ, posted by ed_uk on July 12, 2005, at 17:48:05
Hey Ed!
Thanks, Ed. Just trying to decide whether the Zoloft/Nortriptyline combo may be more effective for me than the Wellbutrin/Zoloft combo. I know I certainly sleep better on Nortriptyline, but the disrupted sleep may go away once I adjust to the Zoloft. Would the nort be a more potent inhibitor of norepiphedrine than Wellbutrin? I guess, I am just investigating my options, so that I can keep the options open. One option that I can also consider, if the nausea from the Wellbutrin/Zoloft combo does not subside, is Zoloft/Nortriptyline with some L-Tyrosine and possibly DMAE along with the occassional dose of NADH. Oh, decisions, decisions. I am a flake :-(
Tamara xoxo
> Hi T!
>
> Although Zoloft has a higher affinity for the dopamine transporter than Wellbutrin, only Wellbutrin has significant dopaminergic effects at therapeutic doses. Zoloft is a very potent serotonin reuptake inhibitor and a very 'weak' dopamine reuptake inhibitor. Therapeutic doses of Zoloft produce low levels of Zoloft in the brain, not enough to affect dopamine reuptake. Because therapeutic doses of Wellbutrin produce high drug levels in the brain, Wellbutrin is believed to inhibit the reuptake of dopamine at normal doses. Wellbutrin has a low affinity for the norepinephrine transporter. Nevertheless, it does have some effect on the reuptake of norepi at therapeutic doses because of the high drug levels produced. Bear in mind, the mechanism of action of Wellbutrin is not well understood. It's various active metabolites also contribute to its AD effect.
>
> >Yet, Nortriptyline seems to be quite a potent or at least be a significant inhibitor of norepiphedrine.
>
> True :-)
>
> Ed xxx
poster:TamaraJ
thread:525731
URL: http://www.dr-bob.org/babble/20050708/msgs/526840.html