Posted by rod on July 8, 2005, at 4:47:14
In reply to Re: COMT Inhibitors? Entacapone is crap for me » ed_uk, posted by rod on July 7, 2005, at 19:39:08
Well, the drug I am thinking about is Depakote/ine (valproic acid)
I have read it leads to increased dopamine release in the prefrontal cortex. Thats the point where my residual symptoms originate I guess. Depakine raises Dopamine activity in certain areas while it also lowers it in other areas. And decreases the activity of the cortisol stuff etc.. like Periactin, like Pentoxifylline and I guess also like Lyrica (there is no study about this. I just experience an anti stress effect)
I would drop Klonopin, Lyrica, Pentoxifylline and replace them with a low dose of Depakote/Depakine.
Well and maybe I am bipolar after all. Atypical. but maybe.
When I was 18/19 the symptoms was insomnia (which I treated with 1-3 beers) and depression (maybe because of the alcohol) with impaired memory, concentration etc.. might be the result of some kind of bipolar neurochmistry. I never had ruminting thoughts, early morning awakening etc.I am going nowhere if I dont change something. I feel relatively good, but still, I am not functioning. I have to do something. I have to change strategy. Now I try the "bipolar route"....
If I think back, almost 2 years ago, I started Lamictal monotherapy. well, while I was gradually increasing my dose, I gradually got "worse". Thats, I guess, when the "antidepressant" effect of Lamictal kicked in.
I have to try a mood stabiliser without any "robust" antidepressant capabiities.And futhermore, despite that I have not read it here, Valporate has a mild mood brightening effect for some people. 1 Monograph mentions this..
If I have the mental energy, I will post the abstracts which make me think Valporate its a good idea.
I hope it wont affect cognition negatively... but who knows.. I just have to give it a try... :-)
oh well,
I have to hurry, time to go to the script writer ;-D
bye
Roland> Hi Ed!
>
> > Will you try a different type of drug instead?
>
> hmm not really. for now, I reduce nortriptyline to 100mg and see how I do with it. and use periactin as needed etc... + all the other drugs
>
> But I am thinking about a "new" approach. Maybe I will change a lot. But I will post about that later..
>
> good night
>
> Roland
>
poster:rod
thread:521642
URL: http://www.dr-bob.org/babble/20050708/msgs/524865.html