Posted by SLS on June 30, 2005, at 17:32:15
In reply to Re: Trileptal is pooping-out on me., posted by linkadge on June 29, 2005, at 20:19:12
> It seems to me that you're getting a lot on the catecholamine side of the ballpark, with the parnate and the nortryptaline. Doesn't seem like you are getting enough on the serotonin side. Too much dopamine and not enought serotonin leaves you blue.
I don't suffer from sadness or depressed mood. It is more of a loss of interest and motivation, anergia, anhedonia, psychomotor retardation, impairments in concentration and memory, and reduced libido. I eat too much, sleep too much, feel best in the morning - reverse vegetative symptoms. However, there is no mood-reactivity. Hypomania and mania have occurred only in association with antidepressant treatment.
> Can you think of any tweeking that would give you more serotogenic neuotransmission ??
>
> Have you tried Nardil ?Nardil produces more of a mood-brightening effect than does Parnate. However, it does poop-out.
> Maybe simplification would yield results.It has taken quite a bit of time to arrive at this combination. I think simplification will be the goal once remission is achieved. In the meantime, the only thing about the combination that creates problems is the use of an MAOI. It is possible that Effexor or Cymbalta could replace the Parnate eventually, but optimizing the Trileptal is the priority at this juncture.
> Have you tried the Nardil / Depakote combination ?No. However, the addition of Depakote to Parnate or clorgyline has not yielded adequate results. Funny, though. When I first start Depakote, I do experience a mild antidepressant effect. Thereafter, it tends to make me feel worse.
> I have a **million** other cool ideas,
It only takes one. :-)
I am very interested to hear your ideas. I have a great deal of respect for the scope and depth of your knowledge and understanding, as well as the intelligence with which you synthesize your own ideas. I would consider any input you would offer me as being very valuable.
I'll turn on my Babble-Mail if you would like to correspond directly.
If Trileptal doesn't work, mifepristone is the next stop for this train.
I only wish that you could more easily profit from your own ideas. I can't fully appreciate the frustration you must experience for not being able to have access to the drugs that you feel might work. I can only say that you have my best wishes for the attainment of health, regardless of where you find it.
Thanks.
- Scott
poster:SLS
thread:520955
URL: http://www.dr-bob.org/babble/20050627/msgs/521644.html