Posted by Questionmark on June 15, 2005, at 18:41:48
In reply to Nardil + Effexor...I'm going for it!!!!, posted by ace on June 12, 2005, at 1:45:31
i believe Effexor is a much more potent SRI (serotonin reuptake inhibitor) than Tramadol is. i could see how a little extra 5-HT reuptake inhibition would make you feel "that old Nardil euphoria," but i question whether it would be worthwhile. Even if it is, you should definitely be extremely cautious and start w/ a very very low dose of SSRI. But as ChairmanMAO said, i think you might be better off using 5-HTP or tryptophan (and/or maybe even something like inositol as well)-- while still being cautious w/ those.
After experimenting w/ minimally low doses of Paxil w/ my Nardil (very rarely & occasionally) to determine how much i might be able to safely take that would also be effective in the way i desired,... i got to the point of using a low dose of Paxil every now and then (again, very very rarely) to powerfully augment my Nardil and get a strong serotonergic effect for a day. i did this for various reasons, but primarily just when i wanted to be in a highly prosocial and happy state for whatever particular reason. (((i STRONGLY RECOMMEND AGAINST THIS PRACTICE FOR ANYONE HOWEVER, FOR A # OF REASONS))).
i would use about 2.5mg - 7mg-- maybe a bit higher (up to 10mg?), but i can't remember for sure-- when on either 45 or 60mg Nardil per day (those are the Nardil doses i have always been on). i have only done this several times or so.
So, firstly, you might be able to go above the absolute maximum doses of Effexor that Chairman MAO mentions (since Paxil is more potent than Effexor, by weight)-- depending on your current dose of Nardil and % MAO inhibition-- but, i really strongly caution against this... (unless maybe you know some brilliant psychopharmacologist who insists that it is fine and explains why).
...
The reasons for this: (1)Who knows what this does to your brain and neurochemistry, especially doing it daily {{[E.g., what if it eventually results in profound apathy and/or inhibition of DA transmission; what if it eventually results in profound 5-HT receptor adaption and tolerance; what if it results in 5-HT neurotoxicity and neuron death (similar to MDMA?)?]}}, (2)Your libido will be eradicated, (3)It may be damaging to your muscles and kidneys, if not more (read about physical effects of serotonin syndrome-- of which your med combo may be a constant at-least-mild form), (4)coma or death due to serotonin syndrome, (5)etc. (?).
Therefore, i advise against it.
Good luck though.> 1. Effexor is like Tramadol, correct???
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> 2. Tramadol makes me feel that old Nardil euphoria
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> 3. Therefore, I'm going to go and try Nardil and Effexor together!
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> Don't worry, i have Periactin and adalat on hand if any probs crop up!!!
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> Please comment, experiences, call me an idiot, a lovely man, etc etc!!
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> Ace!
poster:Questionmark
thread:511331
URL: http://www.dr-bob.org/babble/20050611/msgs/513306.html