Posted by cliffstone on June 14, 2005, at 10:42:09
In reply to Re: Amitriptyline - Therapeutic window or not » cliffstone, posted by ed_uk on June 14, 2005, at 7:54:32
> Hi cliffstone,
>
> >Now I´m on 300 mg with fairly poor results.
>
> Since you're on a high dose, have you had an ECG for safety reasons? Not yet, but in case the amtrip works I will.
>
> >I have found various studies and a few posts on this message board concerning a possible therapeutic window of amitriptyline. By further investigating this topic I found that there are quite a lot of contradicting information.
>
> That's very true. Have you had your blood level measured? Are you having any side effects? No, I haven´t had my blood checked yet. Apart from the usual dry mouth and constipation. Initially I had tachycardia but that´s mostly gone.
>
> In a textbook I've got, the following is suggested........
>
> AMITRIPTYLINE: serum or plasma specimen, trough level ie. >12hrs after the last dose.
>
> Therapeutic: 120-250ng/mL
> Toxic: >500ng/mL
>
> NORTRIPTYLINE: serum or plasma specimen, trough level ie. >12hrs after the last dose.
>
> Therapeutic: 50-150ng/mL
> Toxic: >500ng/mL
>
> Nortriptyline is a metabolite of amitriptyline.
>
> Kind regards,
> Ed.
>
Kind regards
poster:cliffstone
thread:512207
URL: http://www.dr-bob.org/babble/20050611/msgs/512528.html