Posted by ed_uk on June 14, 2005, at 7:54:32
In reply to Amitriptyline - Therapeutic window or not, posted by cliffstone on June 13, 2005, at 18:13:05
Hi cliffstone,
>Now I´m on 300 mg with fairly poor results.
Since you're on a high dose, have you had an ECG for safety reasons?
>I have found various studies and a few posts on this message board concerning a possible therapeutic window of amitriptyline. By further investigating this topic I found that there are quite a lot of contradicting information.
That's very true. Have you had your blood level measured? Are you having any side effects?
In a textbook I've got, the following is suggested........
AMITRIPTYLINE: serum or plasma specimen, trough level ie. >12hrs after the last dose.
Therapeutic: 120-250ng/mL
Toxic: >500ng/mLNORTRIPTYLINE: serum or plasma specimen, trough level ie. >12hrs after the last dose.
Therapeutic: 50-150ng/mL
Toxic: >500ng/mLNortriptyline is a metabolite of amitriptyline.
Kind regards,
Ed.
poster:ed_uk
thread:512207
URL: http://www.dr-bob.org/babble/20050611/msgs/512474.html