Posted by chess on June 7, 2005, at 14:33:22
In reply to Re: Seroquel Pharmacology question » chess, posted by ed_uk on June 7, 2005, at 11:43:58
how can its effect last for up to 20 hours if its half-life is only 6 hours?
> Hi Chess,
>
> >serotonin 5-HT2 occupancy fell even more slowly (half-life, 20 - 27 h)
>
> Occupancy (and therefore antagonism) of 5-HT2 receptors dropped by half after 20-27 hours.
>
> >D2-receptor occupancy declined more slowly (half-life, 6 - 6.4 h)
>
> It's action at D2 receptors may also be important for its anxiolytic effects.
>
> >.......and thus that Seroquel can be taken once-a-day for anxiety?
>
> It might be effective once daily- you'll have to try it and see!
>
> Are you concerned that you might forget to take it if you had to take it more than once daily?
>
> Kind regards,
> Ed.
poster:chess
thread:509023
URL: http://www.dr-bob.org/babble/20050606/msgs/509128.html