Posted by Larry Hoover on May 30, 2005, at 22:43:18
In reply to Re: pellets in capsules » Larry Hoover, posted by Cairo on May 30, 2005, at 8:05:09
> What about Effexor XR? I tried counting out pellets with that and I remember having different effects: one time not much, then another time feeling incredibly spacey (but my muscles completely relaxed for the first and only time since onset of Fibromyalgia). Is Effexor XR one of those that has different coatings on different pellets? That would explain my inconsistent results. Thanks.
I can only speculate. That is an explanation that fits the circumstances. Maybe they fill the capsule in sequence, e.g. 1/3 rapid release, 1/3 delayed release, 1/3 extended release. If you didn't know to mix them up before you separated them into portions, you'd conceivably have different formats in each little pile you made.
I really don't know what they might have done with Effexor specifically. There are so many different microencapsulation processes, each dealing with factors like the solubility and hydophilic (water-loving) or hydrophobic (water-repelled, or fat-loving) nature of the drug, half-life, and so on. There's an entire industry growing up around developing these types of delivery systems.
From the cynical perspection, developing an XR formulation lets them extend the patent. The XR may not be any advance over simple oral pharmacokinetics.
Lar
poster:Larry Hoover
thread:504288
URL: http://www.dr-bob.org/babble/20050527/msgs/505558.html