Posted by temoigneur on May 13, 2005, at 15:35:50
In reply to Re: Clomipramine + prozac = HELP:!!, posted by temoigneur on May 12, 2005, at 20:04:32
> >
Hi Ed,Thank you so much for the feedback. It's strange you know the CLomipraine symptoms seem to be gone, even though I've increased prozac to 50mg. Clomipramine 30, I'm just righting on a hopeful whim that the immovane will continue to work, I took almost about 12 or 13 mg last night, and I slept very well, I just still feel dull on the clomipramine, but I realize that it may be the best for now. I think the prozac definately is helping, and probably making my insomnia worst - I have the luxury of staying with it for the immediate, now that my symptoms have subsided, I'm thinking I'll ask a doctor if I can add bromocriptine if the prozac starts to loose it's effect. I've read that SSRI's over an extended period may cause dopamine blockage/dysfunction in some individuals. And about the trazadone, I didn't take any last night, and slept well, I think it could have been adding to serotonin problems.
The reason why I'm anxious to pursue prozac, is that for one semester in college I felt great on it, and was doing very well in college. Then it just "pooped-out" fairly rapidly, and I've never found the stability since. Now that I've reintroduced prozac after being off them SSRi's/SNRI's for 8 months or so, I guess it makes sense that it may work intially I'm just hoping I can keep it from dying with a dopamine agonist. And thanks for advice about prozac dose and clomipramine blood levels. Perhaps if I get up to 70 mg I'll have to even consider cutting back further on the clomipramine - I'll phone the university speciailists - and I know I need to get a specialist. I'm don't want to go back to my old psychiatrist - I was hoping to get in with someone who's purportedly very good. We'll see Thanks a lot
Ben
Hi Marsha and darkhorse!
> >
> > AFAIK, citalopram can produce a relatively modest increase in the blood levels of nort.
> >
> > >I desperately need the anxiolytic effect of the nortr., asked my pdoc if I should go up on the dose, he said no but then my 15 minutes were up and I couldn't ask why not.
> >
> > Perhaps your pdoc would allow you to gradually increase your nort dose using the 10mg pills.
> >
> > >I am also taking Inderal for anxiety and I fear that it will cancel out the effects of the nort. since inderal blocks norepinephrine in the brain, doesn't it?
> >
> > Inderal sometimes worsens depression. Nadolol (Corgard) might be a better choice of beta blocker.
> >
> > Regards,
> > Ed.
>
> Hi Ed, - I started keeping a record of my experience with prozac and reduced clomip. Unfortunately I got quite bad diahhrea yesterday, and hadn't got up until 4 pm today - I've gotten. Reducing the Clomipramine from 125 to 30mg produced quite bad Diarrhea~: today I've just been up for over 1 1/2 hours, but I seem to have almost no symptoms, That being said however, the prozac causes some insomnia, - I'm hoping by some far fetched logic, that the prozac is uniquely responsive to the immovane, and it will work bettter, once the initial side effects from clomipramine go down. I hope this simply because immovane worked perfectly while the prozac worked for fourth months years ago - but I know this could be wishful thinking.
>
> Ed, I was wondering do you know if a dose of prozac above 20mg, can produce a higher increase in tricylic blood levels, or does the augmentation platues at a low dose of prozac. I was just wondering because on clomipramine the anxiety is gone, but I'm semi vegative, sleeping all day, can't think it's kind of like a 'dumb:) low level europhia, - as I'm going back to school on Friday, I need my mind. so I was taking 50mg prozac/day with the 30mg clomipramine, as I said on the second day, I had the bad side effects. I guess I'll wait, and see how I adjust. Unfortunately I don't have a psychiatrist right now, but the 'anxiety specialist' pdoc who perscribed the Prozac told me there was nothing to worry about concerning Prozac and increase of bloodlevel TCA's.
>
> Anyway basically I was wondering about whether prozac's TCA augmenting effects platued at a low dose, 10 or 20 milligrams, or whether there was thought to be a significantly further increase in TCA blood levels when prozac is raised to 50 - 80mg.
>
> To clomipicate things further, i've been taking trazadone, before immovan to sleep at high levels, (550mg), I'm being really foolish, I know, but it seems to me, I have to an aweful lot to get initial symptoms of seratonin syndrom
> but maybe the gastro intestinal issue is seratonin toxicity.
>
> Ben
poster:temoigneur
thread:494252
URL: http://www.dr-bob.org/babble/20050510/msgs/497407.html