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Re: Does dopamine cancel GABA anxiolysis?

Posted by Chairman_MAO on May 6, 2005, at 9:24:55

In reply to Re: Does dopamine cancel GABA anxiolysis?, posted by Mr.Scott on May 5, 2005, at 20:18:36

IIRC, GABAnergic neurons make up roughly 40% of the brain and are present all over the place. The number of DA neurons--again, IIRC--is only around 20,000-30,000. Thus, it's incoherent to say "dopamine cancel GABA anxiolysis". GABA of course "modulates" DA neurotransmission at times, such as in the "pleasure center" where GABA neurons serve as the "brakes" on the dopaminergic reinforcement mechanism.

Moreover, Increasing GABA indiscriminately is not necessarily anxiolytic at all; ask the many people for whom gabitril made anxiety worse. I think what you're asking is "Will taking a dopaminergic drug cancel out GABAnergic anxiolytics?"

To answer your question in the spirit in which you asked it: no, it does not cancel it out.


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URL: http://www.dr-bob.org/babble/20050504/msgs/494466.html