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Does dopamine cancel GABA anxiolysis?

Posted by cache-monkey on May 3, 2005, at 16:06:19

Hey all,

I'm on a couple pro-GABA meds (ativan and depakote), which I think might be helping with my anxiety. I've read that GABA can clamp down on dopamine, which can result in anergia, anhedonia, dysthymia, etc, which have always been problems for me and have gotten worse since being on these meds.

Does the anti-anxiety effect of GABA come mainly through dopamine supression? Or are there other factors at play?

I'd like to know because one possibility would be to add a dopaminergic drug (e.g. selegiline) to counterbalance my depressed mood. But I'm concerned that doing so would negate the anxiety reduction due to GABA.

Input greatly appreciated.

Best,
cache-monkey


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poster:cache-monkey thread:493198
URL: http://www.dr-bob.org/babble/20050428/msgs/493198.html